I confess, I have a hard time with the Isaiah chapters. The language is difficult to wade through, everything is couched in imagery and metaphors. I always feel like saying: "Just come out and SAY it why don't you!"
For example, verse 22, which says: "Cease ye from man, whose breath is in his nostrils; for wherein is he to be accounted of?" Not exactly straightforward.
Still, I plow through and get the gist of things, even if I don't understand all the imagery and metaphors. And thank goodness for the chapter summaries at the top of the page to help clarify things! Thanks to that help, I know that verse 22 is part of the verses talking about how "The proud and wicked shall be brought low at the Second Coming."